What is the standard treatment for group A strep pharyngitis?

The standard treatment for group A streptococcal (GAS) pharyngitis, commonly known as strep throat, is penicillin V (PCN V). This antibiotic is favored because it is effective against Streptococcus pyogenes, the bacteria responsible for this condition. Penicillin is also well-tolerated, has a relatively low risk for adverse effects, and prevents complications associated with untreated strep throat, such as rheumatic fever and post-streptococcal glomerulonephritis.

Amoxicillin is also a viable option and is frequently prescribed due to its improved taste and ease of administration, especially in children. However, the first-line recommendation is penicillin V because it has a long history of successful treatment outcomes and is specifically recommended by clinical practice guidelines.

While cephalexin and erythromycin can also be used in cases of penicillin allergy or resistance, they are not considered first-line treatments for uncomplicated strep throat. Cephalexin is a cephalosporin antibiotic, which may not be necessary for a straightforward case given that penicillin is effective. Erythromycin is an alternative for those allergic to penicillin, but it is typically reserved for those specific scenarios rather than used